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KMID : 0616120170480030237
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 3 p.237 ~ p.242
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Monitoring and Risk Assessment of Benzo(a)pyrene Content in Medicinal Herbs
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Lee Sae-Ram
Kim Ae-Kyung
Kim Sung-Dan
Lee Hyun-Kyung
Lee Hee-Jin
Ryu Hoe-Jin
Lee Jeong-Mi
Yoo In-Sil
Jung Kweon
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Abstract
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In this study, to investigate of safety for Benzo(a)pyrene in medicinal herb, 8 kinds of selected commercial herbal medicines (Rehmanniae Radix, Rehmanniae Radix Preparata, Amomi Tsao-Ko Fructus, Cimicifugae Rhizoma, Cyperi Rhizoma, Magnoliae Cortex, Scutellariae Radix, Scrophulariae Radix) were analysed using the high performance liquid chromatography with fluorescence detector and assessed the health risk. The levels of benzo(a)pyrene were from non-detection to 28.1 μg/kg, and the average was 3.6 μg/kg. Based on a nationwide survey of the consumption of medicinal herb by the Korean population, we estimated the potential risk from the ingestion of benzo(a)pyrene. The estimated daily intake of benzo(a)pyrene was 1.6 ng/kg b.w./day for group only know the daily average intake of medicinal herb. The MOE (margin of exposure) of benzo(a)pyrene for estimate of health risk was 1.93×105 . Therefore, health risk from benzo(a)pyrene through intake of herbal medicine was considered negligible.
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KEYWORD
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Benzo(a)pyrene , Medicinal herbs , Risk assessment , Margin of exposure
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